Triethylamine → (6-Hydrazineylpyridin-3-yl)(morpholino)methanone

HRID 601002노트

반응식

HRID 601002 반응식
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[NH2:16][NH2:17].C(N(CC)CC)C>C(O)C>[NH:16]([C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1)[NH2:17]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 9321HydrazineHCID 8574994-(6-Chloropyridine-3-carbonyl)morpholine

생성물 1

HCID 58976910(6-Hydrazineylpyridin-3-yl)(morpholino)methanone수율 76%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
100 °C

실험 절차

To (6-chloro-pyridin-3-yl)-morpholin-4-yl-methanone (0.649 g, 2.86 mmoles) in ethanol (6 mL) was added 0.270 uL (3.0 equivalents) of hydrazine, followed by triethylamine 438.9 uL (1.1 equivalents). The reaction was stirred overnight at 100° C. to give (6-hydrazino-pyridin-3-yl)-morpholin-4-yl-methanone. The reaction was filtered and then concentrated to dryness. The crude residue, (6-hydrazino-pyridin-3-yl)-morpholin-4-yl-methanone, weighed 0.372 g (76% yield).

출처 및 근거

ORD 기록
ord-b81e3be765cf412393d4b99adf072e2d
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902239B2

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