2-Amino-5-bromobenzenesulfonamide → N-[2-(aminosulfonyl)pyridin-3-yl]-1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

HRID 601130

반응식

HRID 601130 반응식
[CH2:1]([N:8]1C2C(=CC=CN=2)[C:11]([OH:18])=[C:10]([C:19](OCC)=[O:20])[C:9]1=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:25][C:26]1[C:27]([S:32]([NH2:35])(=[O:34])=[O:33])=[N:28][CH:29]=[CH:30][CH:31]=1.N[C:37]1[CH:42]=[CH:41][C:40](Br)=[CH:39][C:38]=1S(N)(=O)=O>>[NH2:35][S:32]([C:27]1[C:26]([NH:25][C:19]([C:10]2[C:9](=[O:24])[N:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:37]3[C:42]([C:11]=2[OH:18])=[CH:41][CH:40]=[CH:39][CH:38]=3)=[O:20])=[CH:31][CH:30]=[CH:29][N:28]=1)(=[O:34])=[O:33]

참가 물질

4

반응물 3

HCID 8207002-Amino-5-bromobenzenesulfonamideHCID 149437023-Aminopyridine-2-sulfonamideHCID 54729304Ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

생성물 1

HCID 67063771N-[2-(aminosulfonyl)pyridin-3-yl]-1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

실험 절차

The title compound was prepared according to the procedure of Example 84C substituting the product of Example 99A for the product of Example 84B and substituting (3-amino-pyrid-2-yl)sulfonamide for 2-amino-5-bromobenzenesulfonamide to give the crude product as an off white solid.

출처 및 근거

ORD 기록
ord-8cc6185c60fa4265bfed7f1d844674c5
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902203B2

연결된 노트

불러오는 중…