Butyl bromide → 1-[(2-methyl-1,3-thiazol-5-yl)methyl]-2H-3,1-benzoxazine-2,4(1H)-dione

반응식

[NH:1]1[C:6]2N=[CH:8][CH:9]=[CH:10][C:5]=2[C:4](=[O:11])[O:3][C:2]1=[O:12].[CH3:13][C:14]1[S:15][C:16]([CH2:19]Cl)=[CH:17][N:18]=1.[CH2:21](Br)CCC>>[CH3:13][C:14]1[S:15][C:16]([CH2:19][N:1]2[C:6]3[CH:21]=[CH:8][CH:9]=[CH:10][C:5]=3[C:4](=[O:11])[O:3][C:2]2=[O:12])=[CH:17][N:18]=1

참가 물질

반응물 3

HCID 8002Butyl bromide

HCID 109865823-Azaisatoic anhydride

HCID 128087945-(Chloromethyl)-2-methyl-1,3-thiazole

생성물 1

HCID 865921161-[(2-methyl-1,3-thiazol-5-yl)methyl]-2H-3,1-benzoxazine-2,4(1H)-dione

실험 절차

The title compound was prepared according to the procedure of Example 1B substituting isatoic anhydride for the product of Example 1A and 2-methyl-5-chloromethylthiazole for n-butyl bromide to give (0.410 g, 73%).