Ammonium Hydroxide → HCID 15864348, 화합물

반응식

[NH2:1][C:2]1[C:7]([S:8](Cl)(=[O:10])=[O:9])=[CH:6][C:5]([CH3:12])=[CH:4][N:3]=1.[OH-].[NH4+:14]>>[NH2:1][C:2]1[C:7]([S:8]([NH2:14])(=[O:10])=[O:9])=[CH:6][C:5]([CH3:12])=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 189487872-aMino-5-Methylpyridine-3-sulfonyl chloride

생성물 1

HCID 15864348HCID 15864348, 화합물

실험 절차

The product of Example 104A was reacted with concentrated ammonium hydroxide at ambient temperature overnight. The reaction mixture was concentrated to give the title compound as a light yellow solid in quantitative yield. MS (DCI/NH3) m/z 188 (M+H)+. 1H NMR (300 MHz, DMSO-d6) δ 2.17 (m, 3H), 6.28 (s, 2H), 7.43 (s, 2H), 7.70 (d, J=1.84 Hz, 1H), 8.00 (d, J=2.21 Hz, 1H).

후처리

concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록: ord-1509d5ad77c547238f72ebc85086f684
출처 데이터셋: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07902203B2

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