Bromopentafluorobenzene → 4-Nitro-2',3',4',5',6'-pentafluorobiphenyl

HRID 601452

반응식

HRID 601452 반응식
I[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.Br[C:12]1[C:17]([F:18])=[C:16]([F:19])[C:15]([F:20])=[C:14]([F:21])[C:13]=1[F:22]>[Cu]>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([C:12]2[C:13]([F:22])=[C:14]([F:21])[C:15]([F:20])=[C:16]([F:19])[C:17]=2[F:18])=[CH:3][CH:4]=1)([O-:10])=[O:9]

참가 물질

4

반응물 2

HCID 9578BromopentafluorobenzeneHCID 124951-Iodo-4-nitrobenzene

생성물 1

HCID 112547604-Nitro-2',3',4',5',6'-pentafluorobiphenyl수율 63.4%

시약·촉매·용매 1

HCID 23978Copper촉매

반응 조건

온도
190 °C

실험 절차

A mixture of 4-iodonitrobenzene (15 g, 0.060 mol), bromopentafluorobenzene (14.9 g, 2.56 mL, 0.060 mol) and copper powder (30 g) was placed into a 50-mL J-Young glass tube and heated at 190° C. for 24 hours. The tube was cooled and the mixture was extracted exhaustively with dichloromethane. The solvent was removed and the residue was extracted with boiling hexane and filtered while hot. The solvent was removed and the resulting viscous solid was sublimed to obtain 4-nitro-2′,3′,4′,5′,6′-pentafluorobiphenyl as a yellow solid (11.0 g, 63% yield).

후처리

  1. customwas placed into a 50-mL J-Young glass tube
  2. temperatureThe tube was cooled
  3. extractionthe mixture was extracted exhaustively with dichloromethane
  4. customThe solvent was removed
  5. extractionthe residue was extracted with boiling hexane
  6. filtrationfiltered while hot
  7. customThe solvent was removed

출처 및 근거

ORD 기록
ord-adca81a513a1436a87ff1d0673b1d03f
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902363B2

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