Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-Methoxy-4-nitro-phenyl)-4-triisopropylsilanyloxy-piperidine → 3-Methoxy-4-(4-triisopropylsilanyloxy-piperidin-1-yl)-phenylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-Methoxy-4-nitro-phenyl)-4-triisopropylsilanyloxy-piperidine | HCID 57501700 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-Methoxy-4-(4-triisopropylsilanyloxy-piperidin-1-yl)-phenylamine | HCID 57501706 | 100.3% |
반응 단계
Dissolve 1-(2-Methoxy-4-nitro-phenyl)-4-triisopropylsilanyloxy-piperidine (1.53 g, 3.74 mmol) in THF (30 mL) and add 5% Pd/C then stir the slurry at room temperature under a hydrogen atmosphere for 3 h. Filter the black mixture through a pad of Celite® and concentrate the filtrate in vacuo to give 3-methoxy-4-(4-triisopropylsilanyloxy-piperidin-1-yl)-phenylamine (1.42 g, 100%) that was used immediately.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07902356B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-81acc41c2427466fa3067f1be0088242 |
| 출처 메모 | uspto-grants-2011_03 |