Chlorosulfonic acid → 2-Fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride

HRID 601614노트

반응식

HRID 601614 반응식
[Cl:1][S:2]([OH:5])(=O)=[O:3].[F:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14](=[O:16])[CH3:15])=[CH:9][CH:8]=1>>[F:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][C:14](=[O:16])[CH3:15])=[CH:11][C:12]=1[S:2]([Cl:1])(=[O:5])=[O:3]

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 521187(4-Fluorophenyl)acetone

생성물 1

HCID 858617322-Fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride

실험 절차

To a stirred flask of chlorosulphonic acid (344 g, 2.96 mol) cooled to −10° C. is added dropwise 1-(4-fluoro-phenyl)-propan-2-one (10 g, 65 mmol). The reaction mixture is left stirring at room temperature overnight and then poured carefully onto ice. The resultant solution is extracted with ethyl acetate and the organic extracts combined, dried (MgSO4) and concentrated in vacuo to yield the titled compound.

후처리

  1. waitThe reaction mixture is left
  2. additionpoured carefully onto ice
  3. extractionThe resultant solution is extracted with ethyl acetate
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-2829276b9dfd4f709ad209f0573e4351
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902375B2

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