Sodium Sulfite → 2-Fluoro-5-(2-oxo-propyl)-benzenesulfinic acid sodium salt

HRID 601615노트

반응식

HRID 601615 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=1[S:12](Cl)(=[O:14])=[O:13].S([O-])([O-])=O.[Na+:20].[Na+].C(=O)([O-])O.[Na+]>O1CCOCC1.O>[Na+:20].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=1[S:12]([O-:14])=[O:13]

참가 물질

6

반응물 3

HCID 24437Sodium SulfiteHCID 516892Sodium BicarbonateHCID 858617322-Fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride

생성물 1

HCID 671597242-Fluoro-5-(2-oxo-propyl)-benzenesulfinic acid sodium salt

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

반응 조건

온도
70 °C

실험 절차

To a stirred solution of 2-fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride (AG1) (16.25 g, 86.36 mmol) in dioxane (200 ml) is added dropwise a solution of sodium sulfite (16.38 g, 130 mmol) and sodium hydrogen carbonate (10.92 g, 130 mmol) in water (200 ml). The reaction mixture is heated to 70° C. for 20 minutes and then allowed to cool to room temperature. The solvent is removed in vacuo and the resultant residue is used crude in the next step.

후처리

  1. temperatureto cool to room temperature
  2. customThe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-ae99693c83e746f596f9960fb0895181
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902375B2

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