1-Bromo-2-butanone → 6-Bromo-2-ethylimidazo[1,2-a]pyridine

HRID 601666노트

반응식

HRID 601666 반응식
Br[CH2:2][C:3](=O)[CH2:4][CH3:5].[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][N:9]=1>C(O)C>[Br:14][C:11]1[CH:12]=[CH:13][C:8]2[N:9]([CH:2]=[C:3]([CH2:4][CH3:5])[N:7]=2)[CH:10]=1

참가 물질

4

반응물 2

HCID 131561-Bromo-2-butanoneHCID 706222-Amino-5-bromopyridine

생성물 1

HCID 231582656-Bromo-2-ethylimidazo[1,2-a]pyridine수율 64.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5.0 g of 1-bromo-2-butanone was dissolved in 80 ml of ethanol, 5.71 g of 2-amino-5-bromopyridine was added, and the mixture was stirred all night by heating under reflux. After cooling down to room temperature, the solvents were distilled outunder reduced pressure, and ethyl acetated followed by saturated sodium bicarbonate aqueous solution were added. After drying organic layer with anhydrous sodium sulfate, the solvents were distilled outunder reduced pressure. The obtained residues were purified by preparative thin-layer silicagel chromatography (hexane:ethyl acetate=75:25), to obtain 4.82 g of the above compound as a white solid.

후처리

  1. temperatureby heating
  2. temperatureunder reflux
  3. distillationthe solvents were distilled outunder reduced pressure, and ethyl
  4. additionwere added
  5. dry with materialAfter drying organic layer with anhydrous sodium sulfate
  6. distillationthe solvents were distilled outunder reduced pressure
  7. customThe obtained residues were purified by preparative thin-layer silicagel chromatography (hexane:ethyl acetate=75:25)

출처 및 근거

ORD 기록
ord-abd7cd04bb6643c68ca00741e741bc78
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902369B2

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