trans-3,5-Difluorocinnamic acid → 3-(3,5-Difluorophenyl)propionic acid

HRID 601706

반응식

HRID 601706 반응식
[F:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([OH:13])=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1>[Pd].C(OCC)(=O)C.C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1

참가 물질

5

반응물 1

HCID 5374941trans-3,5-Difluorocinnamic acid

생성물 1

HCID 36694983-(3,5-Difluorophenyl)propionic acid수율 99%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

To palladium on activated charcoal (10 wt %, 2.5 g) was added a solution of (E)-3-(3,5-difluorophenyl)acrylic acid (25 g) in a mixture of ethyl acetate (100 mL) and ethyl alcohol (400 mL). The mixture was put on hydrogenator on 50 psi for 6 h. The catalyst was filtered and the solvent was removed to give 25.0 g the title compound (99% yield): 1H NMR (CDCl3, 500 MHz) δ 2.67 (2H, t, J=10 Hz), 2.93 (2H, t, J=10 Hz), 6.65 (1H, m), 6.72 (2H, m).

후처리

  1. filtrationThe catalyst was filtered
  2. customthe solvent was removed

출처 및 근거

ORD 기록
ord-9bcada9b9e39424d88d9fb37f030a313
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902218B2

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