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Pyridine → 3-Benzothiazol-2-yl-3,5-dichloro-1,3-dihydroindol-2-one

HRID 601757
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인쇄 미리보기

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HRID 601757 반응식
N1C=CC=CC=1.S(Cl)(Cl)=O.[S:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:13]=[C:12]1[C:20]1(O)[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([Cl:29])[CH:27]=2)[NH:22][C:21]1=[O:30].[Cl-:32].[NH4+]>ClCCl>[S:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:13]=[C:12]1[C:20]1([Cl:32])[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([Cl:29])[CH:27]=2)[NH:22][C:21]1=[O:30]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 25517Ammonium ChlorideHCID 575177503-Benzothiazol-2-yl-5-chloro-3-hydroxy-1,3-dihydroindol-2-one

생성물 1

HCID 575177513-Benzothiazol-2-yl-3,5-dichloro-1,3-dihydroindol-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane
용매

반응 조건

온도
0 °C

실험 절차

Pyridine (0.57 ml) and thionyl chloride (0.42 ml) were successively added to an ice-cooled solution of the intermediate from step A (1.27 g, 4.0 mmol) in dichloromethane (40 ml). The reaction mixture was stirred at 0° C. for 1 h and then saturated ammonium chloride solution was added. The organic phase was dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude intermediate was rapidly employed without further purification in the next step.

후처리

  1. dry with materialThe organic phase was dried over magnesium sulfate
  2. filtrationfiltered
  3. concentrationconcentrated under reduced pressure
  4. customThe crude intermediate was rapidly employed without further purification in the next step

출처 및 근거

ORD 기록
ord-d32d109e19234893bb42c27cd7b101a9
출처 데이터셋
uspto-grants-2011_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07902379B2

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