Pyridine → 3,5-Dichloro-3-(2-methoxypyridin-3-yl)-1,3-dihydroindol-2-one

HRID 601763노트

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HRID 601763 반응식
N1C=CC=CC=1.S(Cl)(Cl)=O.[Cl:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][C:16](=[O:21])[C:15]2([C:23]1[C:24]([O:29][CH3:30])=[N:25][CH:26]=[CH:27][CH:28]=1)O.[Cl-:31].[NH4+]>ClCCl>[Cl:31][C:15]1([C:23]2[C:24]([O:29][CH3:30])=[N:25][CH:26]=[CH:27][CH:28]=2)[C:14]2[C:18](=[CH:19][CH:20]=[C:12]([Cl:11])[CH:13]=2)[NH:17][C:16]1=[O:21]

참가 물질

6

반응물 4

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 25517Ammonium ChlorideHCID 575177575-Chloro-3-(2-methoxypyridin-3-yl)-3-hydroxy-1,3-dihydroindol-2-one

생성물 1

HCID 575177583,5-Dichloro-3-(2-methoxypyridin-3-yl)-1,3-dihydroindol-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

Pyridine (0.33 ml) and thionyl chloride (0.30 ml) were added successively to an ice-cold solution of the intermediate from step A (1.1 g, 3.44 mmol) in dichloromethane (10 ml). The reaction mixture was stirred at 0° C. for 1 h and then saturated ammonium chloride solution was added. The organic phase was dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude intermediate was rapidly employed without further purification in the next step.

후처리

  1. dry with materialThe organic phase was dried over magnesium sulfate
  2. filtrationfiltered
  3. concentrationconcentrated under reduced pressure
  4. customThe crude intermediate was rapidly employed without further purification in the next step

출처 및 근거

ORD 기록
ord-12c4a0a003fe4855b3d1f66a76691ff0
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902379B2

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