Tetrahydrofuran → N-(2-methylcyclopentyl)-3-methoxy-4-(2-propynyloxy)benzamide

HRID 601983

반응식

HRID 601983 반응식
C1COCC1.Cl.[CH3:7][CH:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[NH2:13].C(N(CC)CC)C.[CH3:21][O:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][C:31]=1[O:32][CH2:33][C:34]#[CH:35])[C:26](Cl)=[O:27]>O>[CH3:7][CH:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[NH:13][C:26](=[O:27])[C:25]1[CH:29]=[CH:30][C:31]([O:32][CH2:33][C:34]#[CH:35])=[C:23]([O:22][CH3:21])[CH:24]=1

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 191014392-Methylcyclopentan-1-amine hydrochlorideHCID 574456713-Methoxy-4-(2-propynyloxy)benzoyl chloride

생성물 1

HCID 57445683N-(2-methylcyclopentyl)-3-methoxy-4-(2-propynyloxy)benzamide수율 36.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of 20 ml of THF, 0.50 g of 2-methylcyclopentylamine hydrochloride and 1.0 g of triethylamine was added 0.50 g of 3-methoxy-4-(2-propynyloxy)benzoyl chloride. The mixture obtained was stirred at room temperature for 3 hours. Then, water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was dried and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 235 mg of N-(2-methylcyclopentyl)-3-methoxy-4-(2-propynyloxy)benzamide (hereinafter, described as the compound 18 of the present invention) represented by the formula:

후처리

  1. customThe mixture obtained
  2. extractionthe mixture was extracted with ethyl acetate
  3. customThe organic layer was dried
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-1bf4ea1c1e584c7eb2436317bd392241
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902400B2

연결된 노트

불러오는 중…