Tetrahydrofuran → N-cyclopentylmethyl-3,5-dimethoxy-(2-propynyloxy)benzamide

HRID 601988

반응식

HRID 601988 반응식
C1C[O:4][CH2:3]C1.[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:14]=[C:15]([O:21][CH3:22])[C:16]=1OCC#C)[C:11](Cl)=[O:12].[CH:23]1([CH2:28][NH2:29])[CH2:27][CH2:26][CH2:25][CH2:24]1.C(N([CH2:35][CH3:36])CC)C>C(OCC)(=O)C>[CH:23]1([CH2:28][NH:29][C:11](=[O:12])[C:10]2[CH:14]=[C:15]([O:21][CH3:22])[CH:16]=[C:8]([O:7][CH3:6])[C:9]=2[O:4][CH2:3][C:35]#[CH:36])[CH2:27][CH2:26][CH2:25][CH2:24]1

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 80153CyclopentanemethylamineHCID 574456693,5-Dimethoxy-4-(2-propynyloxy)benzoyl chloride

생성물 1

HCID 86630486N-cyclopentylmethyl-3,5-dimethoxy-(2-propynyloxy)benzamide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a mixture of 5 ml of THF and 0.30 g of 3,5-dimethoxy-4-(2-propynyloxy)benzoyl chloride were added 0.15 g of 1-(cyclopentyl)methylamine and 0.21 g of triethylamine in order at room temperature. The mixture obtained was stirred at room temperature for 1 hour. Then, ethyl acetate was added to the reaction mixture and the mixture was filtered through Celite. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.13 g of N-cyclopentylmethyl-3,5-dimethoxy-(2-propynyloxy)benzamide (hereinafter, described as the compound 30 of the present invention) represented by the formula:

후처리

  1. customThe mixture obtained
  2. filtrationthe mixture was filtered through Celite
  3. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-015122d8d0994657b0da4eacfc1f8910
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902400B2

연결된 노트

불러오는 중…