Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propargyl alcohol → N-cyclohexylmethyl-4-(2-propynyloxy)-3,5-difluorobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propargyl alcohol | HCID 7859 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | N-cyclohexylmethyl-3,4,5-trifluorobenzamide | HCID 57445689 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-cyclohexylmethyl-4-(2-propynyloxy)-3,5-difluorobenzamide | HCID 57445690 | 86.5% |
반응 단계
To 10 ml of DMF were added 0.50 g of N-cyclohexylmethyl-3,4,5-trifluorobenzamide and 0.15 g of propargyl alcohol and to the mixture obtained was added 100 mg of sodium hydride at 0° C. The mixture obtained was stirred at room temperature for 2 hours. Then, the reaction mixture was concentrated. The residue was subjected to silica gel column chromatography to obtain 0.49 g of N-cyclohexylmethyl-4-(2-propynyloxy)-3,5-difluorobenzamide (hereinafter, described as the compound 32 of the present invention) represented by the formula:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07902400B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-654479aa1bb64bec9802d847b74d6aaa |
| 출처 메모 | uspto-grants-2011_03 |