Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N-(2-methylcyclopentyl)-3,5-difluoro-4-(2-propynyloxy)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Methylcyclopentylamine | HCID 409747 | — |
| 반응물 | 3,5-Difluoro-4-(2-propynyloxy)benzoyl chloride | HCID 57445696 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-(2-methylcyclopentyl)-3,5-difluoro-4-(2-propynyloxy)benzamide | HCID 57701151 | 23.9% |
반응 단계
A mixture of 0.12 g of 2-methylcyclopentylamine, 0.2 ml of triethylamine and 1 ml of ethyl acetate was added dropwise under ice cooling to a mixture of 1 ml of ethyl acetate and 0.23 g of 3,5-difluoro-4-(2-propynyloxy)benzoyl chloride. The mixture obtained was stirred at room temperature for 12 hours. Then, the reaction mixture was subjected to silica gel column chromatography to obtain 0.07 g of N-(2-methylcyclopentyl)-3,5-difluoro-4-(2-propynyloxy)benzamide (hereinafter, described as the compound 54 of the present invention) represented by the formula:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07902400B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-71eadf54d06749b79c25711ed5634508 |
| 출처 메모 | uspto-grants-2011_03 |