Triethylamine → N-(2-methylcyclopentyl)-3,5-dimethoxy-4-(2-propynyloxy)benzamide

HRID 601999

반응식

HRID 601999 반응식
Cl.[CH3:2][CH:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[NH2:8].C(N(CC)CC)C.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH:24]=[C:25]([O:31][CH3:32])[C:26]=1[O:27][CH2:28][C:29]#[CH:30])[C:21](Cl)=[O:22]>C(OCC)(=O)C>[CH3:2][CH:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[NH:8][C:21](=[O:22])[C:20]1[CH:19]=[C:18]([O:17][CH3:16])[C:26]([O:27][CH2:28][C:29]#[CH:30])=[C:25]([O:31][CH3:32])[CH:24]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 191014392-Methylcyclopentan-1-amine hydrochlorideHCID 574456693,5-Dimethoxy-4-(2-propynyloxy)benzoyl chloride

생성물 1

HCID 57701153N-(2-methylcyclopentyl)-3,5-dimethoxy-4-(2-propynyloxy)benzamide수율 67.4%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

To a mixture of 1 ml of ethyl acetate and 0.2 g of 2-methylcyclopentylamine hydrochloride was added 0.48 ml of triethylamine and then, a mixture of 0.25 g of 3,5-dimethoxy-4-(2-propynyloxy)benzoyl chloride and 1 ml of ethyl acetate was added dropwise thereto under ice cooling. The mixture obtained was stirred at room temperature for 12 hours. Then, the reaction mixture was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.21 g of N-(2-methylcyclopentyl)-3,5-dimethoxy-4-(2-propynyloxy)benzamide (hereinafter, described as the compound 68 of the present invention) represented by the formula:

후처리

  1. additionwas added dropwise
  2. customThe mixture obtained
  3. concentrationThen, the reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2c8844ad818a46f1947c88d603eaaa41
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902400B2

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