Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → N-(2-methylcyclopentyl)-3,4-difluorobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3,4-Difluorobenzoyl chloride | HCID 2724519 | — |
| 반응물 | 2-Methylcyclopentan-1-amine hydrochloride | HCID 19101439 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-(2-methylcyclopentyl)-3,4-difluorobenzamide | HCID 57445707 | 84.3% |
반응 단계
To a mixture of 10 ml of THF and 0.60 g of 3,4-difluorobenzoyl chloride were added 0.37 g of 2-methylcyclopentylamine hydrochloride and 1.0 g of triethylamine, and the mixture obtained was stirred at room temperature for 3 hours. Then, ethyl acetate was added to the reaction mixture and filtered through Celite. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.55 g of N-(2-methylcyclopentyl)-3,4-difluorobenzamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07902400B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-8ab286347c77495d9716b68571a0fd09 |
| 출처 메모 | uspto-grants-2011_03 |