Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → 6-(2-Fluorophenyl)nicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Tert-butyl 6-(2-fluorophenyl)nicotinate | HCID 67267995 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 6-(2-Fluorophenyl)nicotinic acid | HCID 24729971 | 98.7% |
반응 단계
To tert-butyl 6-(2-fluorophenyl)nicotinate (479 mg, 1.75 mmol) in DCM (12 mL) at 0° C. was added TFA (2.5 mL). After stirring at rt overnight, toluene was added (10 mL) and the solvent removed to give a white solid (375 mg, 98%), 6-(2-fluorophenyl)nicotinic acid. LC/MS (M+H)=218.0 observed, 218.06 expected.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07902373B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-e8914897738a41368082a8bb2d310a98 |
| 출처 메모 | uspto-grants-2011_03 |