4-Benzylmorpholine-2-carboxylic acid hydrochloride → Methyl 4-benzylmorpholine-2-carboxylate

HRID 602131

반응식

HRID 602131 반응식
Cl.[CH2:2]([N:9]1[CH2:14][CH2:13][O:12][CH:11]([C:15]([OH:17])=[O:16])[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl.[CH3:19]O>>[CH2:2]([N:9]1[CH2:14][CH2:13][O:12][CH:11]([C:15]([O:17][CH3:19])=[O:16])[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 27763524-Benzylmorpholine-2-carboxylic acid hydrochlorideHCID 21893726Hydrochloride methanol

생성물 1

HCID 50989152Methyl 4-benzylmorpholine-2-carboxylate수율 80%

실험 절차

4-Benzylmorpholine-2-carboxylic acid hydrochloride (1.00 g, 3.88 mmol) in a 10 (w/w) % hydrochloric acid/methanol solution (20 mL) was stirred at room temperature for 2 hours. The solvent was evaporated and a saturated aqueous sodium bicarbonate solution was added to the residue to make the mixture basic. The mixture was then extracted with ethyl acetate and the extract washed with brine and was dried over magnesium sulfate. Evaporation of the solvent gave 730 mg (80%) of the desired compound as a colorless oil.

후처리

  1. customThe solvent was evaporated
  2. additiona saturated aqueous sodium bicarbonate solution was added to the residue
  3. extractionThe mixture was then extracted with ethyl acetate
  4. washthe extract washed with brine
  5. dry with materialwas dried over magnesium sulfate
  6. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-71ee93e16bae4d76a593d200f4928bb8
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902367B2

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