Water → 3-[4-(4-Fluorophenoxy)benzyloxy]piperidine

HRID 602186노트

반응식

HRID 602186 반응식
[OH-].[K+].FC(F)(F)C([N:7]1[CH2:12][CH2:11][CH2:10][CH:9]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)=[CH:17][CH:16]=2)[CH2:8]1)=O.O>CO>[F:28][C:25]1[CH:26]=[CH:27][C:22]([O:21][C:18]2[CH:17]=[CH:16][C:15]([CH2:14][O:13][CH:9]3[CH2:10][CH2:11][CH2:12][NH:7][CH2:8]3)=[CH:20][CH:19]=2)=[CH:23][CH:24]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 589925921-Trifluoroacetyl-3-[4-(4-fluorophenoxy)benzyloxy]piperidine

생성물 1

HCID 589926953-[4-(4-Fluorophenoxy)benzyloxy]piperidine수율 95.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A 1 mol/L aqueous potassium hydroxide solution (2 mL) was added to 1-trifluoroacetyl-3-[4-(4-fluorophenoxy)benzyloxy]piperidine (434 mg, 1.09 mmol) in methanol (4 mL). The mixture was refluxed for 2 hours and was allowed to cool. Water was then added and the mixture was extracted with ethyl acetate. The organic layer was washed with brine and the washed product was dried over magnesium sulfate. The solvent was evaporated to give 314 mg (95%) of the desired compound as a colorless oil.

후처리

  1. temperatureThe mixture was refluxed for 2 hours
  2. temperatureto cool
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialthe washed product was dried over magnesium sulfate
  6. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-595462e0dfde48798d401963a45daa78
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902367B2

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