Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Iodide → [2-(4-Chlorophenyl)-4-methylthiazol-5-yl]methyltriphenylphosphonium iodide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole | HCID 2763694 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | [2-(4-Chlorophenyl)-4-methylthiazol-5-yl]methyltriphenylphosphonium iodide | HCID 86615887 | — |
반응 단계
Triphenylphosphine (1.15 g, 4.26 mmol) and sodium iodide (580 mg, 3.87 mmol) were added to 5-chloromethyl-2-(4-chlorophenyl)-4-methylthiazole (1.00 g, 3.87 mmol) in tetrahydrofuran (20 mL). The reaction mixture was stirred for 5 hours while being stirred. Subsequently, the crystallized powdery product was collected by filtration and washed with hexane to give 2.43 g (quant.) of the desired compound as a colorless powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07902367B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-d31d6f1021094d158b4e074d81c7946f |
| 출처 메모 | uspto-grants-2011_03 |