Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(R)-1-Boc-3-hydroxypiperidine → (R)-1-(tert-Butoxycarbonyl)-3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxy]piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (R)-1-Boc-3-hydroxypiperidine | HCID 1514398 | — |
| 반응물 | 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole | HCID 2763694 | — |
| 생성물 | (R)-1-(tert-Butoxycarbonyl)-3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxy]piperidine | HCID 58992677 | 78.5% |
반응 단계
In an argon atmosphere, (R)-1-(tert-butoxycarbonyl)-3-hydroxypiperidine (604 mg, 3.00 mmol) and 5-chloromethyl-2-(4-chlorophenyl)-4-methylthiazole (775 mg, 3.00 mmol) were reacted in the same manner as in Step 6a of Example 6 to give 996 mg (78%) of the desired compound as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07902367B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-5243581fe5414ec389a0b6226dd06ac1 |
| 출처 메모 | uspto-grants-2011_03 |