Guanidine Hydrochloride → 4-Pyrimidinecarboxylic acid, 2-amino-, methyl ester
반응식
C(N(CC)CC)C.C(O[CH:13]=[CH:14][C:15](=O)[C:16]([O:18][CH3:19])=[O:17])CCC.Cl.[NH2:22][C:23]([NH2:25])=[NH:24]>C(#N)CC>[NH2:25][C:23]1[N:24]=[C:15]([C:16]([O:18][CH3:19])=[O:17])[CH:14]=[CH:13][N:22]=1참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
Triethylamine (29 mL, 210 mmol) was added to a suspension of methyl 4-butoxy-2-oxo-3-butenate (37 g, 200 mmol, JP-A-2003-89690) and guanidine hydrochloride (23 g, 240 mmol) in propionitrile (50 mL), and the mixture was stirred for 4 hours at 100° C. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give 18 g as the mixture of the title Reference Compound and the butyl ester form of the title Reference compound as a gray-white solid (Yield: 60%).
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe residue was purified by silica gel column chromatography
- customto give 18 g
- additionas the mixture of the title Reference Compound
출처 및 근거
- ORD 기록
- ord-75d1a1db9a334ec6b2d8775becfed182
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07906511B2
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