Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloroaniline → tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloroaniline | HCID 7812 | — |
| 반응물 | 2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline | HCID 27833 | — |
| 반응물 | (2R)-1-[(tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid | HCID 688022 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate | HCID 9138711 | — |
반응 단계
4.82 g (19.5 mmol) of ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate (EEDQ) are added to a suspension of 2.80 g (13.0 mmol) of N-Boc-D-proline and 1.66 g (13.0 mmol) of 4-chloroaniline in 50 ml of toluene, and the mixture is stirred at room temperature for 3 hours. The reaction mixture is filtered, and petroleum ether is added to the filtrate. The precipitate formed is filtered off and dried, giving tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate as colourless crystals; ESI 325.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07906516B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-3d4be8b56c6e4a41abd341a00e524224 |
| 출처 메모 | uspto-grants-2011_03 |