5-fluoro-1H-indazole-3-carboxylic acid → tert-Butyl (2S,4S)-4-{[(5-fluoro-1H-indazol-3-yl)carbonyl]amino}-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate

HRID 602493노트

반응식

HRID 602493 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[C:11]([OH:13])=O.[NH2:14][C@@H:15]1[CH2:19][N:18]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[C@H:17]([CH2:27][C:28]([O:30][CH3:31])=[O:29])[CH2:16]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[C:11]([NH:14][C@@H:15]1[CH2:19][N:18]([C:20]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:21])[C@H:17]([CH2:27][C:28]([O:30][CH3:31])=[O:29])[CH2:16]1)=[O:13]

참가 물질

3

반응물 2

HCID 149990525-fluoro-1H-indazole-3-carboxylic acidHCID 67271206tert-butyl (2S,4S)-4-amino-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate

생성물 1

HCID 67270785tert-Butyl (2S,4S)-4-{[(5-fluoro-1H-indazol-3-yl)carbonyl]amino}-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate

실험 절차

The title compound was prepared according to the procedure described in step 1 of Example 7 from 5-fluoro-1H-indazole-3-carboxylic acid (J. Heterocyclic Chem. 1964, 1, 239) and tert-butyl (2S,4S)-4-amino-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate (step 4 of Example 9).

출처 및 근거

ORD 기록
ord-60e8476d009e4d55b65612d7652bbfa5
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906532B2

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