Trifluoroacetic acid → 3-[1-(3,5-Difluorophenyl)-2,2-dimethylpropylidene]azetidine

HRID 602705노트

반응식

HRID 602705 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[C:14]2[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]2)[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:5]=[C:6]([F:8])[CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([C:9](=[C:14]2[CH2:15][NH:16][CH2:17]2)[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:5]=[C:6]([F:8])[CH:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67065934Tert-butyl 3-[1-(3,5-difluorophenyl)-2,2-dimethylpropylidene]azetidine-1-carboxylate

생성물 1

HCID 670658933-[1-(3,5-Difluorophenyl)-2,2-dimethylpropylidene]azetidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 210 mg (0.623 mmol) of tert-butyl 3-[1(3,5-difluorophenyl)-2,2-dimethylpropylidene]azetidine-1-carboxylate in 1 mL of CH2Cl2, was added 1.5 mL of TFA followed by stirring for 1 h at rt. The reaction mixture was concentrated and washed with ether to afford the title compound as white solid; Mass Spectrum: m/e=238 (M+1).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. washwashed with ether

출처 및 근거

ORD 기록
ord-f1c9ff4245b641ccaa998e0b73d7f950
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906503B2

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