Trifluoroacetic acid → 3-[1-(3,5-Difluorophenyl)-2,2-dimethylpropyl]azetidine
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([CH:14]2[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]2)[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:5]=[C:6]([F:8])[CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:9]([CH:14]2[CH2:15][NH:16][CH2:17]2)[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:5]=[C:6]([F:8])[CH:7]=1참가 물질
4
실험 절차
To a solution of 360 mg (1.06 mmol) of tert-butyl 3-[1-(3,5-difluorophenyl)-2,2-dimethylpropyl]azetidine-1-carboxylate in 1.5 mL of CH2Cl2, was added 1.5 mL of TFA and the solution was stirred for 1 h at rt. It was concentrated and washed with ether to afford the title compound as a white solid; Mass Spectrum: m/e=240 (M+1).
후처리
- concentrationIt was concentrated
- washwashed with ether
출처 및 근거
- ORD 기록
- ord-65ce462f0c084cc1b537ebfdab5c30e1
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07906503B2
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