참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Methylbenzoxazole | HCID 7225 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 촉매 | Benzoyl Peroxide | HCID 7187 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | 2-(Bromomethyl)benzo[d]oxazole | HCID 12745944 | 17% |
반응 단계
A solution of 35 g (0.263 mol) of 2-methyl-benzooxazole in CCl4 (300 mL) was treated with 47 g (0.263, 1 eq) of NBS and 1 g of benzoyl peroxide. The mixture was refluxed (100° C.) over night then cooled. Succinimide was filtered off and the mixture was evaporated to dryness. Column chromatography yielded 9.2 g (17%) of 2-bromomethyl-benzooxazole as a light yellow oil, MS: 210, 212 (MH+). (H. Uno, M. Kurokawa, Y. Masuda, Chem. Pharm. Bull., 1981, 29, 2359).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07906546B2 |
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| 출처 데이터셋 | uspto-grants-2011_03 |
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| ORD ID | ord-9ecd94bb63d24f9eb45f6d9f4213f937 |
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| 출처 메모 | uspto-grants-2011_03 |
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