Ethyl Acetate → Ethyl 2-methyl-1,3-oxazole-4-carboxylate
반응식
[CH2:1]([O:3][C:4]([C:6]([N:9]=[C:10]([O:12][CH2:13]C)[CH3:11])=C[O-])=[O:5])[CH3:2].[K+].CCOC(C)=O.C([O-])(O)=O.[Na+]>C(O)(=O)C>[CH2:1]([O:3][C:4]([C:6]1[N:9]=[C:10]([CH3:11])[O:12][CH:13]=1)=[O:5])[CH3:2]참가 물질
5
반응 조건
- 온도
- 110 °C
실험 절차
5 g (25 mmol) of potassium 2-ethoxycarbonyl-2-(1-ethoxy-ethylideneamino)-ethenolate were completely dissolved in 15 mL acetic acid at RT, and then the solution was heated to 110° C. overnight. After cooling down, 100 mL EtOAc were added and the solution is neutralized with saturated NaHCO3 solution. The organic phase was separated, dried over Na2SO4, filtered and evaporated. Column chromatography on silica gel (heptane/EtOAc 1:2) yielded 1.74 g (45%) of 2-methyl-oxazole-4-carboxylic acid ethyl ester as an yellow oil, MS: 156 (MH+).
후처리
- temperatureAfter cooling down
- customThe organic phase was separated
- dry with materialdried over Na2SO4
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-c04230959fd24adb8c67e3a051985410
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07906546B2
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