Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
8-(2,4,5-Trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene → 8-(2,4,5-Trifluorophenyl)-1,4-dioxaspiro[4.5]decane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 8-(2,4,5-Trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene | HCID 57424360 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 8-(2,4,5-Trifluorophenyl)-1,4-dioxaspiro[4.5]decane | HCID 57424361 | — |
반응 단계
A solution of 8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene in methanol (240 mL) and ethyl acetate (5 mL) was treated with 10% palladium on carbon (7.0 g) and stirred under an atmosphere of hydrogen gas (40 psig) overnight. The reaction mixture was filtered over Celite. The filtrate was concentrated and chromatographed (silica gel, gradient 5-7% ethyl acetate in hexane) to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07906649B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-022b8f1566d547fb8d88fdae0bcb18d5 |
| 출처 메모 | uspto-grants-2011_03 |