Methyl 4-[bromo(3-cyanophenyl)methyl]benzoate → Methyl 4-((S)-(3-cyanophenyl){3-[(1S)-1-(3,5-difluorophenyl)-2-fluoro-2-methylpropyl]azetidin-1-yl}methyl)benzoate
반응식
Br[CH:2]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]#[N:20])[CH:14]=1)[C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][CH:4]=1.[F:21][C:22]1[CH:23]=[C:24]([C@H:29]([CH:34]2[CH2:37][NH:36][CH2:35]2)[C:30]([F:33])([CH3:32])[CH3:31])[CH:25]=[C:26]([F:28])[CH:27]=1>>[C:19]([C:15]1[CH:14]=[C:13]([C@@H:2]([N:36]2[CH2:37][CH:34]([C@@H:29]([C:24]3[CH:23]=[C:22]([F:21])[CH:27]=[C:26]([F:28])[CH:25]=3)[C:30]([F:33])([CH3:31])[CH3:32])[CH2:35]2)[C:3]2[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][CH:4]=2)[CH:18]=[CH:17][CH:16]=1)#[N:20]참가 물질
3
실험 절차
The title compound was prepared methyl 4-[bromo(3-cyanophenyl)methyl]benzoate and 3-[(1S)-1-(3,5-difluorophenyl)-2-fluoro-2-methylpropyl]azetidine (Step 1, Preparation 15) by the procedure described in Step 2 of Preparation 15. The product was purified by chromatography on an AD column using 30% isopropanol-heptane to afford the title compound; 1H-NMR(CDCl3) δ 1.25 (t, J=22 Hz, 6H), 2.33 (t, J=6.5 Hz, 1H), 2.83-2.89 (m, 2H), 3.05-3.22 (m, 2H), 3.65 (m, 1H), 3.92 (s, 3H), 4.34 (s, 1H), 6.68-6.71 (m, 3H), 7.21-7.8 (m, 8H); Mass Spectrum: m/e=493 (M+1).