Boron tribromide → 4-Bromocatechol
반응식
[Br:1][C:2]1[CH:3]=[C:4]([O:10]C)[C:5]([O:8]C)=[CH:6][CH:7]=1.B(Br)(Br)Br>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]([OH:10])[C:5](=[CH:6][CH:7]=1)[OH:8]참가 물질
4
실험 절차
6.51 g (0.0300 mol) of 4-bromoveratrole is dissolved in 50 ml of dichloromethane. To this suspension is added 37.6 g (0.150 mol) of boron tribromide at 0° C. The mixture was stirred for 3 hours at room temperature. Solvents were removed under reduced pressure. The resulting brown oil was dissolved in ethyl acetate and filtered through a pad of silica gel. The filtrate was concentrated to afford 5.45 g of 4-bromo catechol as a fight, brown oil.
후처리
- customSolvents were removed under reduced pressure
- dissolutionThe resulting brown oil was dissolved in ethyl acetate
- filtrationfiltered through a pad of silica gel
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-78a19679612140a9b7842b32d540d6c0
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07906648B2
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