참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | 2-Pyridinamine, 5-iodo- | HCID 88579 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-(5-Iodo-pyridin-2-YL)-4-methyl-benzenesulfonamide | HCID 21772024 | 86.2% |
반응 단계
A mixture of 5-iodopyridin-2-amine (25.5 g), 4-methylbenzene-1-sulfonyl chloride (23.2 g) and pyridine (250 mL) was stirred at 100° C. overnight. The reaction mixture was poured into water (1.2 L) and stirred. The resulting solid was collected by filtration. The obtained solid was washed with water and diethyl ether and dried in vacuo to give the title compound (37.4 g) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09440987B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-2f3fa683d20e43d580c697040c92e7b9 |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
