Triethylamine → HCID 131737089, 화합물

HRID 60383노트

반응식

HRID 60383 반응식
[Br:1][C:2]1[O:6][C:5]([CH:7]=[CH:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.C(N(CC)CC)C.ClC(OCC)=O.[N-:25]=[N+:26]=[N-:27].[Na+]>C(#N)C>[Br:1][C:2]1[O:6][C:5]([CH:7]=[CH:8][C:9]([N:25]=[N+:26]=[N-:27])=[O:11])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 33557Sodium AzideHCID 9460883-(5-Bromofuran-2-yl)prop-2-enoic acid

생성물 1

HCID 131737089HCID 131737089, 화합물수율 44.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 3-(5-bromo-2-furyl)acrylic acid (41.5 g) in acetonitrile (200 mL) were added triethylamine (23.0 g) and ethyl chloroformate (26.1 g). The mixture was stirred at room temperature for 30 min. To the obtained mixture was added a saturated aqueous solution of sodium azide (18.7 g) at 0° C. and the mixture was stirred at room temperature for 5 hr. The reaction mixture was filtered, and the obtained solid was washed with water. The solid was recrystallized from dichloromethane to give the title compound (20.7 g) as white solid.

후처리

  1. stirringthe mixture was stirred at room temperature for 5 hr
  2. filtrationThe reaction mixture was filtered
  3. washthe obtained solid was washed with water
  4. customThe solid was recrystallized from dichloromethane

출처 및 근거

ORD 기록
ord-f311bd1396044febb1d35e93ccc5e430
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440987B2

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