Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Hydroxyacetophenone → 3-acetylphenyl 2,3,4-tri-O-acetyl-5-thio-beta-D-xylopyranoside
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Hydroxyacetophenone | HCID 8487 | — |
| 반응물 | 2,3,4-Tri-o-acetyl-5-thioxylopyranosyl bromide | HCID 11382683 | — |
| 촉매 | Zincchloride | HCID 3007855 | — |
| 촉매 | Silver imidazolate | HCID 10931941 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-acetylphenyl 2,3,4-tri-O-acetyl-5-thio-beta-D-xylopyranoside | HCID 15067852 | 14% |
반응 단계
If the procedure described in Preparation LXXXIII is followed starting from 3.45 g (25.3.10-3 mol) of 1-(3-hydroxyphenyl)ethanone, 6 g (16.9.10-3 mol) of 2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide, 3 g (17.10-3 mol) of silver imidazolate and 4.6 g (33.7.10-3 mol) of zinc chloride in 90 ml of methylene chloride and 30 ml of acetonitrile, 0.96 g (yield: 14%) of the expected product is obtained after purification by chromatography on silica gel using a toluene/ethyl acetate mixture (6/1 v/v) as the eluent, and crystallization from ether.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05246961 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-fe312a64789d4aa28cb765688102371f |
| 출처 메모 | uspto-grants-1993_09 |