Tetrahydrofuran → 1,4-Dimethyl-6-hexadecyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

HRID 60399

반응식

HRID 60399 반응식
[CH3:1][N:2]1[C:6]2=[N:7][C:8]([CH3:12])=[CH:9][C:10]([CH3:11])=[C:5]2[CH2:4][CH2:3]1.[Li][CH2:14][CH2:15][CH2:16][CH3:17].Br[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].[CH2:28]1COC[CH2:29]1>>[CH3:1][N:2]1[C:6]2=[N:7][C:8]([CH2:12][CH2:17][CH2:16][CH2:15][CH2:14][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:28][CH3:29])=[CH:9][C:10]([CH3:11])=[C:5]2[CH2:4][CH2:3]1

참가 물질

5

반응물 4

HCID 8028TetrahydrofuranHCID 127421-BromononaneHCID 141770291,4,6-Trimethyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridineHCID 178418339Butyllithium

생성물 1

HCID 716778991,4-Dimethyl-6-hexadecyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

실험 절차

To a solution of 277 mg (1.71 mmol) of 1,4,6-trimethyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine in 5 mL of THF was added 1.71 mL (2.73 mmol, 1.6 M in hexanes) of n-BuLi followed by 518 μL (1.79 mmol) of 1-bromononane at 78° C. The reaction mixture was slowly warmed to room temperature and stirred for another 16 h. The reaction mixture was quenched by the addition of 10 mL of sat aq NH4Cl at 0° C. The mixture was extracted with EtOAc. The combined organic layer was Washed with brine, dried (MgSO4) and concentrated under diminished pressure. The residue was purified by flash chromatography on a silica gel column (25 3.2 cm). Elution with 10:1 hexanes/ethyl acetate gave the product as a white solid: yield 330 mg (52%); mp 43-45° C.; silica gel TLC Rf 0.25 (8:1:1 hexanes/ethyl acetate/MeOH); 1H NMR (CDCl3) δ 0.88 (t, 3H, J=7.2 Hz), 1.25-1.31 (m, 28H), 1.66 (quint, 2H, J=7.6 Hz), 2.08 (s, 3H), 2.55 (t, 2H, J=8.0 Hz), 2.80 (t, 2H, J=8.4 Hz), 2.90 (s, 3H), 3.38 (t, 2H, J=8.4 Hz) and 6.13 (s, 1H); 13C NMR (CDCl3) δ 14.1, 18.0, 22.7, 24.4, 29.38, 29.38, 29.57, 29.62, 29.65, 29.68, 29.72, 29.72, 29.72, 29.72, 29.72, 29.72, 30.0, 32.0, 33.2, 38.1, 52.4, 112.4, 118.2, 141.0, 159.1 and 163.7; mass spectrum, m/z 372.3 (M+) (theoretical 372.4); mass spectrum (APCI), m/z 373.3574 (M+H)+ (C25H45N2 requires 373.3583).

후처리

  1. customThe reaction mixture was quenched by the addition of 10 mL of sat aq NH4Cl at 0° C
  2. extractionThe mixture was extracted with EtOAc
  3. washThe combined organic layer was Washed with brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated under diminished pressure
  6. customThe residue was purified by flash chromatography on a silica gel column (25 3.2 cm)
  7. washElution with 10:1 hexanes/ethyl acetate

출처 및 근거

ORD 기록
ord-cc5177d09d07468481b96bcbbadf3d3c
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440967B2

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