Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Hydroxybenzonitrile → 2-cyanophenyl 2,3,4-tri-O-acetyl-5-thio-beta-D-xylopyranoside
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Hydroxybenzonitrile | HCID 11907 | — |
| 반응물 | 2,3,4-tri-O-acetyl-5-thio-alpha-xylopyranosyl bromide | HCID 10926314 | — |
| 촉매 | Zincchloride | HCID 3007855 | — |
| 촉매 | Silver imidazolate | HCID 10931941 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-cyanophenyl 2,3,4-tri-O-acetyl-5-thio-beta-D-xylopyranoside | HCID 15067854 | 20% |
반응 단계
If the procedure described in Preparation LXXXIII is followed starting from 2 g (16.8.10-3 mol) of 2-hydroxybenzonitrile, 4.4 g (25.1.10-3 mol) of silver imidazolate, 6.5 g (18.3.10-3 mol) of 2,3,4-tri-O-acetyl-5-thio-α-D-xylopyranosyl bromide and 4.6 g (33.6.10-3 mol) of zinc chloride in 80 ml of methylene chloride, 1.32 g (yield: 20%) of the expected product are obtained after purification by chromatography on silica gel using a toluene/ethyl acetate mixture (6/1 v/v) as the eluent, and precipitation in ether.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05246961 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-231454abe7284d98adfcccdd34ddb1a5 |
| 출처 메모 | uspto-grants-1993_09 |