Thionyl Chloride → 1-Bromo-2-(chloromethyl)-4,5-dimethoxybenzene
반응식
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH3:11])=[CH:4][C:3]=1[CH2:12]O.S(Cl)([Cl:16])=O>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH3:11])=[CH:4][C:3]=1[CH2:12][Cl:16]참가 물질
4
실험 절차
(2-Bromo-4,5-dimethoxy-phenyl)-methanol (2.47 g) is dissolved in methylene chloride (30 ml) and thereto is added thionyl chloride (875 μl), and the mixture is stirred at room temperature for 30 minutes. The reaction solution is concentrated under reduced pressure, and thereto is added hexane and the resulting crystal is filtered to give 1-bromo-2-chloromethyl-4,5-dimethoxy-benzene (2.25 g). MS (m/z): 229/231
후처리
- concentrationThe reaction solution is concentrated under reduced pressure
- additionis added hexane
- filtrationthe resulting crystal is filtered
출처 및 근거
- ORD 기록
- ord-7d6b77474a7641058318025df334334e
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07906517B2
반응 노트
불러오는 중…