Sodium Azide → HCID 178520396, 화합물
반응식
[C:1]1([C:6]([CH2:8][C:9]#[N:10])=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.[N-:11]=[N+:12]=[N-:13].[Na+].[Cl-].C([NH+](CC)CC)C>C1(C)C=CC=CC=1>[NH:11]1[C:9]([CH2:8][C:6]([C:1]2[S:5][CH:4]=[CH:3][CH:2]=2)=[O:7])=[N:10][N:13]=[N:12]1참가 물질
5
실험 절차
A mixture of 2-thenoylacetonitrile (9 g, 59.3 mmol), Sodium azide (4.33 g, 66.7 mmol) and triethylammoniumchloride (9.14 g, 66.9 mmol) was stirred in dry toluene (139 mL) under argon atmosphere at 90° C. for 18 hrs. A two-phase system was formed, cooled and extracted with NaOH (2M, 3×500 mL), and the aqueous solution was poured into hydrochloric acid (4M, 300 mL) and the crude tetrazole was filtered off and recrystalised from acetonitrile. Yield: 43.5%.
후처리
- customA two-phase system was formed
- temperaturecooled
- extractionextracted with NaOH (2M, 3×500 mL)
- additionthe aqueous solution was poured into hydrochloric acid (4M, 300 mL)
- filtrationthe crude tetrazole was filtered off
- customrecrystalised from acetonitrile
출처 및 근거
- ORD 기록
- ord-c651cd26f6604ce8ae8f81049a65b97f
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07910613B2
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