Triethylamine → HCID 57709615, 화합물

HRID 604492노트

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HRID 604492 반응식
[NH2:1][C:2]1[S:3][C:4]([C:13]([NH:15][NH2:16])=[O:14])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.C(N(CC)CC)C.[C:24](N1C=CN=C1)(N1C=CN=C1)=[O:25]>O1CCCC1>[NH2:1][C:2]1[S:3][C:4]([C:13]2[O:14][C:24](=[O:25])[NH:16][N:15]=2)=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 14819492-amino-4-phenyl-1,3-thiazole-5-carbohydrazide

생성물 1

HCID 57709615HCID 57709615, 화합물수율 20%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-Amino-4-phenyl-thiazole-5-carboxylic acid hydrazide (1 g, 4.3 mmol) was suspended in tetrahydrofurane (50 mL). Triethylamine (5 mL, 40 mmol) and carbonyldiimidazole (0.83, 5.1 mmol) was added. The reaction mixture was stirred at room temperature for 1 h. The solvent was removed in vacuo. The crude product was purified by flash column chromatography, eluted with the ethyl acetate/hexanes (1/1) to give the product as a solid. Yield: 20%.

후처리

  1. customThe solvent was removed in vacuo
  2. customThe crude product was purified by flash column chromatography
  3. washeluted with the ethyl acetate/hexanes (1/1)

출처 및 근거

ORD 기록
ord-0f6bc6830d7c4a508f5a3bf6d5c4a137
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910613B2

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