Trifluoroacetic acid → Trifluoroacetic acid

HRID 605116노트

반응식

HRID 605116 반응식
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([S:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:30])[NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Br:29])[CH:24]=3)=[CH:17][C:16]=2[NH:31][C:32]2[C:33]3[CH:41]=[CH:40][C:39]([CH3:42])=[N:38][C:34]=3[N:35]=[CH:36][N:37]=2)=[CH:10][CH:9]=1)(C)(C)C.[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47]>C(Cl)Cl>[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([S:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Br:29])[CH:24]=3)=[O:30])=[CH:17][C:16]=2[NH:31][C:32]2[C:33]3[CH:41]=[CH:40][C:39]([CH3:42])=[N:38][C:34]=3[N:35]=[CH:36][N:37]=2)=[CH:10][CH:9]=1.[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47]

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 67040669{4-[4-(3-Bromo-phenylcarbamoyl)-2-(7-methyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester

생성물 2

HCID 6422Trifluoroacetic acidHCID 670409784-(4-Amino-phenylsulfanyl)-N-(3-bromo-phenyl)-3-(7-methyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The product of Example 66 was treated with trifluoroacetic acid (3 mL) in methylene chloride (3 mL) at room temperature for 30 minutes. The solvents were removed under vacuum to provide the title compound as a trifluoroacetic acid salt. 1H NMR (300 MHz, DMSO-D6) δ ppm: 2.77 (s, 3 H) 6.65 (d, J=8.46 Hz, 2 H) 6.97 (d, J=8.46 Hz, 1 H) 7.16 (d, J=8.46 Hz, 2 H) 7.30 (m, 2 H) 7.72 (m, 1 H) 7.90 (m, 3 H) 8.05 (s, 1 H) 8.92 (s, 1 H) 9.01 (d, J=8.46 Hz, 1 H) 10.36 (s, 1 H) 11.78 (s, 1 H); MS (ESI+) m/z 557, 559 (M+H)+.

후처리

  1. customThe solvents were removed under vacuum

출처 및 근거

ORD 기록
ord-b81b2b9de656449287c14953131a8f83
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910595B2

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