Trifluoroacetic acid → 4-(4-Amino-phenoxy)-N-(4-bromo-phenyl)-3-nitro-benzamide

HRID 605136노트

반응식

HRID 605136 반응식
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:30])[NH:22][C:23]3[CH:28]=[CH:27][C:26]([Br:29])=[CH:25][CH:24]=3)=[CH:17][C:16]=2[N+:31]([O-:33])=[O:32])=[CH:10][CH:9]=1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH:22][C:23]3[CH:28]=[CH:27][C:26]([Br:29])=[CH:25][CH:24]=3)=[O:30])=[CH:17][C:16]=2[N+:31]([O-:33])=[O:32])=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67040702{4-[4-(4-Bromo-phenylcarbamoyl)-2-nitro-phenoxy]phenyl}-carbamic acid tert-butyl ester

생성물 1

HCID 670405064-(4-Amino-phenoxy)-N-(4-bromo-phenyl)-3-nitro-benzamide수율 97.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of the product of Example 10B (250 mg, 0.4732 mmol) in methylene chloride (5 mL) was treated with trifluoroacetic acid (5 mL) at room temperature for 30 minutes. The solvents were removed by rotary evaporation under vacuum, and the residue taken up in ethyl acetate (100 mL) and washed with saturated aqueous sodium hydrogen carbonate (2×50 mL), water (50 mL), and brine (50 mL). The organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum to provide the title compound as a light orange solid (197 mg, 97%).

후처리

  1. customThe solvents were removed by rotary evaporation under vacuum
  2. washwashed with saturated aqueous sodium hydrogen carbonate (2×50 mL), water (50 mL), and brine (50 mL)
  3. dry with materialThe organic phase was dried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-ab2b9c3289ac4e2fa2c278a73a4f920c
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910595B2

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