3-Amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl ester → 4-(4-Methoxy-phenylsulfanyl)-3-(7-methyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid methyl ester

HRID 605178노트

반응식

HRID 605178 반응식
[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[C:6]([NH2:19])[CH:5]=1.C([C:23]1[C:24]([N:30]=[CH:31][N:32]([CH3:34])C)=[N:25][C:26]([CH3:29])=[CH:27][CH:28]=1)#N>>[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[C:6]([NH:19][C:34]2[C:23]3[CH:28]=[CH:27][C:26]([CH3:29])=[N:25][C:24]=3[N:30]=[CH:31][N:32]=2)[CH:5]=1

참가 물질

3

반응물 2

HCID 613055833-Amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl esterHCID 66808573N'-(3-Cyano-6-methyl-pyridin-2-yl)-N,N-dimethyl-formamidine2회

생성물 1

HCID 670403514-(4-Methoxy-phenylsulfanyl)-3-(7-methyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid methyl ester수율 45%

실험 절차

The product from Example 136B (2.67 g, 9.23 mmol) and the product from Example 9B (1.72 g, 9.23 mmol) were reacted according to the procedure from Example 136C substituting the product from Example 9B for the product from Example 8E to give a residue which was purified by silica gel chromatography using 4% methanol in dichloromethane as eluent to provide the title compound as a white solid (1.79 g, 45%).

후처리

  1. customto give a residue which
  2. customwas purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-cb011c4367a347a59028ccf81e759cc9
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910595B2

반응 노트

불러오는 중…