Water → (2R)-2-{[2-Amino-5-(benzylthio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}pentan-1-ol

참여 물질

역할	이름	HCID	투입량
반응물	Water	HCID 962	—
반응물	Diisopropylethylamine	HCID 81531	—
반응물	(2R)-2-aminopentan-1-ol	HCID 5324727	—
반응물	5-(Benzylthio)-7-chloro[1,3]thiazolo[4,5-d]pyrimidin-2-amine	HCID 11278274	—
용매	N-methyl-2-pyrrolidone	HCID 13387	—
생성물	(2R)-2-{[2-Amino-5-(benzylthio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}pentan-1-ol	HCID 59799570	97%

반응 조건

온도	110 °C

반응 단계

5-(Benzylthio)-7-chloro[1,3]thiazolo[4,5-d]pyrimidin-2-amine (6.0 g, 19.4 mmol) was dissolved in NMP (30 mL). DIPEA (8.4 mL, 48.5 mmol) and 2-amino-(2R)-1-pentanol (3.5 g, 33.9 mmol) were added and the mixture was heated to 110° C. for 4 days. After cooling to ambient temperature, the mixture was poured into water (200 mL). The precipitated product was collected by filtration, washed with water and used in the next step without further purification (7.0 g, 97% yield).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09440992B2
출처 데이터셋	uspto-grants-2016_09
ORD ID	ord-4087d4fb568c446f92fd9b64e69d1797
출처 메모	uspto-grants-2016_09