3-Amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl ester → 4-(4-Methoxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid methyl ester

HRID 605280노트

반응식

HRID 605280 반응식
[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[C:6]([NH2:19])[CH:5]=1.C([C:23]1[C:24]([N:29]=[CH:30][N:31]([CH3:33])C)=[N:25][CH:26]=[CH:27][CH:28]=1)#N>>[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[C:6]([NH:19][C:33]2[C:23]3[CH:28]=[CH:27][CH:26]=[N:25][C:24]=3[N:29]=[CH:30][N:31]=2)[CH:5]=1

참가 물질

3

반응물 2

HCID 613055833-Amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl esterHCID 66808319N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidine2회

생성물 1

HCID 670406454-(4-Methoxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid methyl ester

실험 절차

The product from Example 136B and the product from Example 29A were reacted according to the procedure from Example 136C substituting the product from Example 29A for the product from Example 8E to provide the title compound.

출처 및 근거

ORD 기록
ord-63966feeb0d145779c953a9d7fbbe186
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910595B2

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