3-Bromo-N-[5-(4-hydroxy-phenylsulfanyl)-2-methyl-4-nitro-phenyl]-benzamide → N-[4-Amino-5-(4-hydroxy-phenylsulfanyl)-2-methyl-phenyl]-3-bromo-benzamide

HRID 605291노트

반응식

HRID 605291 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[C:5]([NH:7][C:8]1[CH:13]=[C:12]([S:14][C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)[C:11]([N+:22]([O-])=O)=[CH:10][C:9]=1[CH3:25])=[O:6].OC1C=CC(SC2C([N+]([O-])=O)=CC(C)=C(NC(=O)CC3C=CC=CC=3)C=2)=CC=1>>[NH2:22][C:11]1[C:12]([S:14][C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)=[CH:13][C:8]([NH:7][C:5](=[O:6])[C:4]2[CH:26]=[CH:27][CH:28]=[C:2]([Br:1])[CH:3]=2)=[C:9]([CH3:25])[CH:10]=1

참가 물질

3

반응물 2

HCID 670402513-Bromo-N-[5-(4-hydroxy-phenylsulfanyl)-2-methyl-4-nitro-phenyl]-benzamide2회HCID 67041085N-[5-(4-Hydroxy-phenylsulfanyl)-2-methyl-4-nitro-phenyl]-2-phenyl-acetamide

생성물 1

HCID 67040607N-[4-Amino-5-(4-hydroxy-phenylsulfanyl)-2-methyl-phenyl]-3-bromo-benzamide수율 86%

실험 절차

The product from Example 266B was reacted according to the procedure from Example 265C substituting the product from Example 266B for the product from Example 265B to provide the title compound as a brown solid (0.164 g, 86%). This material was utilized without purification by silica gel chromatography.

출처 및 근거

ORD 기록
ord-e534153dea784af89212a3a177600d82
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910595B2

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