N-[5-(4-Hydroxy-phenylsulfanyl)-2-methyl-4-nitro-phenyl]-benzamide → N-[4-Amino-5-(4-hydroxy-phenylsulfanyl)-2-methyl-phenyl]-benzamide

HRID 605293노트

반응식

HRID 605293 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[C:10]([N+:25]([O-])=O)=[CH:11][C:12]([CH3:24])=[C:13]([NH:15][C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:14]=2)=[CH:4][CH:3]=1.OC1C=CC(SC2C([N+]([O-])=O)=CC(C)=C(NC(=O)CC3C=CC=CC=3)C=2)=CC=1>>[NH2:25][C:10]1[C:9]([S:8][C:5]2[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=2)=[CH:14][C:13]([NH:15][C:16](=[O:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:12]([CH3:24])[CH:11]=1

참가 물질

3

반응물 2

HCID 67040761N-[5-(4-Hydroxy-phenylsulfanyl)-2-methyl-4-nitro-phenyl]-benzamide2회HCID 67041085N-[5-(4-Hydroxy-phenylsulfanyl)-2-methyl-4-nitro-phenyl]-2-phenyl-acetamide

생성물 1

HCID 67040289N-[4-Amino-5-(4-hydroxy-phenylsulfanyl)-2-methyl-phenyl]-benzamide수율 100%

실험 절차

The product from Example 267B was reacted according to the procedure from Example 265C substituting the product from Example 267B for the product from Example 265B to provide the title compound as a brown solid (0.11 g, 100%). This material was utilized without purification by silica gel chromatography.

출처 및 근거

ORD 기록
ord-bb73e60440204624b03b795b13312e09
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910595B2

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