참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-Aminophenol | HCID 403 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | N-(4-bromophenyl)-4-chloro-3-nitrobenzamide | HCID 1068537 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(4-Amino-phenoxy)-N-(4-bromo-phenyl)-3-nitro-benzamide | HCID 67040506 | 98.1% |
반응 단계
A mixture of the product from Example 10A (3.55g, 10 mmol), 4-aminophenol (1.09 g, 10 mmol), and potassium hydroxide (1.12 g, 20 mmol) were dissolved in dimethyl sulfoxide (15 mL) and heated at 100° C. in a CEM Discover microwave for 25 minutes. The mixture was then cooled to room temperature, poured into water (300 mL), the pH of the solution adjusted to 6 with 1N aqueous hydrochloric acid, the resultant solution stirred for 30 minutes and the resultant solid collected and dried to provide the title compound as a yellow solid (4.2 g, 98%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07910595B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_03 |
|---|
| ORD ID | ord-d3d78c4f4fe34b559b89262890ea832d |
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| 출처 메모 | uspto-grants-2011_03 |
|---|
