Nitric Acid → HCID 56763846, 화합물

HRID 605310노트

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HRID 605310 반응식
[N+:1]([O-:4])(O)=[O:2].[CH2:5]([O:7][C:8]([C:10]1[S:11][C:12]([Cl:15])=[CH:13][CH:14]=1)=[O:9])[CH3:6]>>[CH2:5]([O:7][C:8]([C:10]1[S:11][C:12]([Cl:15])=[C:13]([N+:1]([O-:4])=[O:2])[CH:14]=1)=[O:9])[CH3:6]

참가 물질

3

반응물 2

HCID 944Nitric AcidHCID 521808Ethyl 5-chlorothiophene-2-carboxylate

생성물 1

HCID 56763846HCID 56763846, 화합물수율 55%

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온도
10 °C

실험 절차

A solution of fuming nitric acid (75 mL) was cooled to 10° C. followed by the addition of 5-chloro-thiophene-2-carboxylic acid ethyl ester (15 g, 78.7 mmol). The resulting mixture was stirred for 30 minutes at 10° C. followed by the addition of ice water. The solution was then extracted with ethyl acetate and dried, then concentrated under vacuum and purified by column chromatography using silica gel to provide 10.29 g (55%) of the title product.

후처리

  1. extractionThe solution was then extracted with ethyl acetate
  2. customdried
  3. concentrationconcentrated under vacuum
  4. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-ab80c8d83b084772a16961669b11eb2b
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910595B2

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